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pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can reduce panobinostat degrees by ~70% and cause treatment method failure.pentobarbital will lower the extent or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/W